Five tastes

Section 4 of 4

Your tongue holds a few thousand taste buds, small clusters of cells, most of them in the bumps on its surface. Their receptors and channels pick up five tastes, and taste buds all over the tongue pick up all five.

The five tastes
TasteWhat the taste cells pick upFound in
sweetsugars such as sucrose and fructosefruit, honey, cake
sourH⁺ from acidslemons, vinegar, yoghurt
saltysodium ions, Na⁺, from saltcrisps, olives, soy sauce
bittermany molecules, picked up by about 25 kinds of bitter receptorcoffee, dark chocolate, tonic water
umamiglutamate, from the amino acid glutamic acidtomatoes, parmesan, mushrooms

Sour is the taste of acid. H⁺ from an acid passes into sour taste cells through a channel made for it, and the cells signal to your brain. The more H⁺, the more sour: lemon juice, at about pH 2, has about 30 times the H⁺ of orange juice, at about pH 3.5, and tastes far sourer.

Umami is a Japanese word for a savoury taste. The chemist Kikunae Ikeda named it in 1908, after he traced the taste of a broth made with kombu seaweed to glutamic acid. In food it is mostly glutamate, the ion glutamic acid becomes once it has given away H⁺ from one of its two -⁠COOH groups.

Sweeter than sugar

The sweet receptor is a protein with a pocket, like every other receptor in this lesson. Sucrose fits it, and some molecules fit it so much better that a pinch of them tastes as sweet as a spoonful of sugar.

Aspartame is built from two amino acids, L-⁠aspartic acid and L-⁠phenylalanine, joined by the same peptide bond that joins the amino acids in a protein. The phenylalanine end is an ester, with a methyl group in place of the H of its -⁠COOH. A chemist found its sweet taste by chance in 1965, when he licked his finger to pick up a sheet of paper.

Aspartame, C₁₄H₁₈N₂O₅A sweetener made from two amino acids, L-aspartic acid and L-phenylalanine, joined by a peptide bond, -CONH-. The phenylalanine end is an ester with a methyl group, and the aspartic acid end keeps its -NH₂ group and a -COOH group.OOOOHONHNH2
Aspartame, C₁₄H₁₈N₂O₅. The peptide bond, -⁠CONH⁠-, joins the aspartic acid part, with its -⁠NH₂ and -⁠COOH groups, to the phenylalanine part, with its benzene ring and the methyl ester.
How many times as sweet as sugar
SweetenerTimes as sweet as sucrose
aspartameabout 200
acesulfame Kabout 200
saccharin200 to 700
sucraloseabout 600
advantameabout 20,000

So little sweetener is needed that it adds almost no energy to a drink. Sucralose is made from sucrose itself: three of its -⁠OH groups are swapped for chlorine atoms.

Quick check

Aspartame is about 200 times as sweet as sugar. About how much aspartame matches the sweetness of 10 g of sugar?

That's the end of lesson 27

In this lesson you found out:

  • How smell receptors turn molecules into patterns your brain reads
  • Why some mirror-image pairs smell different and others smell the same
  • Why chilli feels hot and menthol feels cold
  • What the five tastes pick up, and why sweeteners are needed in such small amounts